# SH2D4A

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Protein-coding gene in the species Homo sapiens

SH2D4A
Identifiers
Aliases | SH2D4A, PPP1R38, SH2A, SH2 domain containing 4A
External IDs | OMIM: 614968 MGI: 1919531 HomoloGene: 11117 GeneCards: SH2D4A

Gene location (Human)
Chr. | Chromosome 8 (human)[1]
Band | 8p21.3 | Start | 19,313,693 bp[1]
End | 19,396,218 bp[1]

Gene location (Mouse)
Chr. | Chromosome 8 (mouse)[2]
Band | 8|8 B3.3 | Start | 68,729,219 bp[2]
End | 68,800,351 bp[2]

RNA expression pattern

Bgee

Top expressed in

- secondary oocyte
- Achilles tendon
- amniotic fluid
- palpebral conjunctiva
- pylorus
- parotid gland
- Right lobe of liver
- pancreatic epithelial cell
- cardia
- vena cava

More reference expression data

BioGPS

More reference expression data

Gene ontology

Molecular function

- GO:0001948 protein binding
- phosphatase binding

Cellular component

- cytoplasm
- cytosol

Biological process

- negative regulation of phosphatase activity

Sources:Amigo / QuickGO

Orthologs
Species | Human | Mouse

Entrez

63898

72281

Ensembl

ENSG00000104611

ENSMUSG00000053886

UniProt

Q9H788

Q9D7V1

RefSeq (mRNA)

NM_001174159 NM_001174160 NM_022071 NM_001363110 NM_001363111

NM_028182

RefSeq (protein)

NP_001167630 NP_001167631 NP_071354 NP_001350039 NP_001350040

NP_082458

Location (UCSC) | Chr 8: 19.31 – 19.4 Mb | Chr 8: 68.73 – 68.8 Mb
PubMed search | [3] | [4]
Wikidata

View/Edit Human | View/Edit Mouse

SH2 domain-containing protein 4A is a protein that in humans is encoded by the SH2D4A gene.[5]

## Interactions[ edit ]

SH2D4A has been shown to interact with MAGEA11.[6]

## References[ edit ]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104611 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053886 - Ensembl, May 2017
3. ^
   "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: SH2D4A SH2 domain containing 4A".
6. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

## Further reading[ edit ]

- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Dai S, Zhao Y, Ding Q (2003). "[A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 19 (6): 458–462. PMID 12476414.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

| This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=SH2D4A&oldid=1081690864"
Categories:

- Genes on human chromosome 8
- Human chromosome 8 gene stubs

Hidden categories:

- Articles with short description
- Short description matches Wikidata
- All stub articles